Abstract

Fanconi anaemia (FA) is an inherited bone marrow failure syndrome (IBMFS) that is common among children, in a ratio of 1 person out of a population of 181 individuals. Early screening and/or detection of FA among intending couples or families with history of IBMFS is very important, to avoid bearing children with physical deformities and high risk of cancer development. The most significant marker for FA diagnosis is the appearance of recurrent patterns of chromosome breakages. Fractures can only be noticeable if chromosome samples are treated with Diepoxybutane (DEB), Mitomicin C (MMC) or other similar chemical treatments. Therefore, a concise clinical protocol for identification of FA was the sole focus of this article.

Statistics